Pathogenesis of heartwater. I. Cowdria ruminantium in the lymph nodes of domestic ruminants.
نویسنده
چکیده
DU PLESSIS, J. L. Pathogenesis of heartwater. I. C01vdria ruminantium in the lymph nodes of domestic ruminants. Onderstepoort f. vet. Res. (1970), 37 (2), 89-96. The intracellular replication of CoJPdria mminanti11111 (Cowdry, 1926) is described in reticulum cells of lymph nodes severa l days prior to the appearance of rickettsial colonies in vascular endothelial cells. This is suggestive of a developmental cycle of the parasite in the lymph nodes. The subinoculation of suspensions of these glands resulted in transmission of the disease.
منابع مشابه
Diagnosis of heartwater at post-mortem in ruminants and the confirmation of Cowdria ruminantium in mice.
Criteria that are required to confirm heartwater in ruminants and mice are discussed. In ruminants it entails the macroscopical and microscopical lesions as well as the identification of Cowdria ruminantium in brain smears or histological sections. Macroscopical lesions in the majority of animals that die of the disease include effusion of body cavities, hydropericardium, oedema of the lungs, b...
متن کاملIdentification of drugs effective against Cowdria ruminantium using a mouse screening system.
Heartwater is a tick-transmitted rickettsial infection of ruminants, caused by Cowdria ruminantium. The tetracyclines are the only compounds available for therapy of the disease. A screen, using mice infected with C. ruminantium, was developed and used to identify new compounds with potential for the control of heartwater. A series of di-4-methyl-thiosemicarbazones was shown to be highly active...
متن کاملA chemically defined medium for the growth of Cowdria ruminantium.
Chemically defined media, termed SFMC-23 and SFMC-36, were devised for the in vitro culture of Cowdria ruminantium, the causative agent of heartwater in domestic ruminants. Both media were based on Dulbecco's modified Eagle's medium nutrient mixture Ham F-12 (DME/F-12) containing various supplements. Medium SFMC-23 and SFMC-36 supported the long-term growth of the Welgevonden stock of C. rumina...
متن کاملThe detection of antibodies cross-reacting with Cowdria ruminantium in the sera of domestic ruminants in regions of South Africa where Amblyomma hebraeum does not occur.
High levels of seropositivity, in all probability attributable to Ehrlichia, were recorded in the serum of domestic ruminants throughout districts in South Africa where Amblyomma hebraeum, the vector of the heartwater agent, does not occur. The antibodies, detected with the indirect fluorescent antibody (IFA) and the indirect ELISA tests, cross-reacted with Cowdria ruminantium, which was used a...
متن کاملHeartwater. The artificial transmission of Cowdria ruminantium in domestic ruminants and mice.
The artificial transmission of Cowdria ruminantium with infected blood, organ homogenates, peritoneal macrophages, tick stabilate and tissue culture cells is discussed. Organ homogenates prepared from the myocardium, spleen, kidneys and liver of diseased animals are commonly used to infect mice. The efficacy of organ homogenates as a source of C. ruminantium depends on factors such as the route...
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ورودعنوان ژورنال:
- The Onderstepoort journal of veterinary research
دوره 37 2 شماره
صفحات -
تاریخ انتشار 1970